Sergey A. Kornilov, PhD
Tagline:Computational Systems Biology | Personalized Medicine | Multi-Omics | Biomarker and Drug Discovery | Biostatistics | Data Science | Neurophysiology | Psychometrics
Seattle, WA, USA
Bio
Strengths & Priorities
I am a dedicated researcher who loves problem solving under uncertainty. My background spans cognitive and behavioral science, neurophysiology, molecular and computational biology, applied statistics, and machine learning. I am most interested in pursuing advances in human health via translational research with a focus on biomarker discovery, multi-omics, and systems biology. I am an experienced researcher, a talented data analyst, and a sharp thinker who has formal training in project management and experience working in and with poly- and cross-functional teams.
I am always open to new collaborations, contract and consulting work, as well as dreaming about new ways to make this world better and humans healthier and happier. Feel free to check out my resume or reach out by e-mail.
Companies I worked with include: Bryleos, Thorne HealthTech, Roche Genentech, Gilead Biosciences, iCarbonX US, Finasteride Association, BioAnalytica, MindTrust, and Arivale. At Arivale, I was a Statistical Geneticist of a direct-to-consumer genetic testing and scientific wellness program. Having worked in both academia and industry and served as the interface between them, I get particularly excited about agile and disruptive projects that small biotech and healthcare tech companies are uniquely poised to execute.
Career Path
My early career focused on measurement and individual differences in human cognitive and personality traits. I have (co)-developed the first psychometric tests of spoken Russian and Arabic development for adults and children, respectively. My interest in individual differences ultimately led to my pursuing hybrid training at UConn (Go Huskies!), Yale, and Haskins Labs that brought together behavior, brain, and genetic data for the first time in a study of developmental language disorders. One of the key outcomes of my graduate research was the discovery of the role of a gene called SETBP1 in developmental language disorders; a finding since robustly replicated by multiple groups. In another line of work, I have established several portable EEG labs and designed a number of cross-modal experimental paradigms to study the neurophysiological effects of adversity and limits of neuroplasticity (this work was supported by the Russian Foundation for Fundamental Research and the National Institutes of Health).
More recently I have focused on multi-omics as applied to the systems biology of human health and disease, with a particular focus on blood proteomics and metabolomics. I was privileged to have worked with some of the most talented people I met at Institute for Systems Biology, including a pioneer in the fields of genomics and precision medicine Dr. Leroy Hood. As a Senior Research Scientist at ISB, I supported its multi-omic and in silico research programs, acted as PI on its UK BioBank Project, and interfaced with external collaborators from pharmaceutical and biotechnology companies. This includes designing, conducting, and analyzing data from observational and clinical trials investigating the systemic effects of therapeutics such as anti-CD20 monoclonal antibodies, statins, and metabolic activators.
Frivolous Bonus
In my free time, I am an avid gamer and baker, a proud pet dad, a loving partner, and a hopeless sensation seeker. It is my firm opinion that one has not lived if one had never tried good Tiramisu, that dogs should be able to pee on grass and cannot read warning signs, and that together we can make this world better.
P.S. I agree with Dr. Avi Loeb: "Science is an expression of love for the Universe". Life sciences are an expression of love for life. Translational science is an expression of love for humanity.
Interests & Expertise
- A.I.-enabled Drug Development and Biomarker Discovery
- Molecular and Computational Systems Biology of Disease and Health
- Multi-Omic Characterization of Longevity, Healthspan, and Well-being
- Precision Medicine and Pharmacogenomics
- Polygenic Risk and Personalized Interventions
- Science-powered Healthcare Product Development
- Innovative High-Risk Interdisciplinary Collaborations
- LLM in Clinical Practice and Client-Patient Interactions
- Evidence-Based Developmental Clinical Science
- Brain Endophenotypes & Brain-Computer Interfaces
Skills & Toolset
- Data Science
- Machine Learning
- Computational Biology
- Biostatistics
- Clinical Trial Design
- *nix/Shell/Jupyter/Docker/AWS/EC2
- R (Expert) & Python (Int.)
- Multi-Omics
- Statistical Genetics
- DNA and RNA Sequencing
- Proteomics (Olink, Soma)
- Neuroimaging & EEG
- Eye Tracking
- Psycholinguistics
- Psychometrics & Assessment
- Project Management
- Technical, Medical, Grant Writing
- CDISC/ADAM/ICH/FDA
Employment
Founder and Research Monad
from: 2024, until: presentOrganization:Biostochastics, LLCLocation:Seattle, WA
Senior Research Scientist 2
from: 2019, until: 2024Organization:Institute for Systems BiologyLocation:Seattle, WA · Hybrid
Description:Health Data Science Group (PI: Dr. Andrew T. Magis)
Research Scientist II - Statistical Genetics
from: 2018, until: 2019Organization:Arivale, IncLocation:Seattle, WA · On-site
Description:Arivale Research Solutions
Research Assistant Professor
from: 2017, until: 2018Organization:University of HoustonLocation:Houston, TX · On-site
Description:Molecular Genetics and Bioinformatics
Texas Institute for Measurement, Evaluation, and StatisticsResearch Scientist
from: 2016, until: 2017Organization:Saint-Petersburg State UniversityLocation:Russia · Hybrid
Description:Department of Psychology
Post-Doc Training
Duncan Scholar in Human and Molecular Genetics
from: 2016, until: 2018Organization:Baylor College of MedicineLocation:Houston, TX
Description:Department of Human and Molecular Genetics
Post-Doctoral Fellow 2
from: 2016, until: 2017Organization:University of HoustonLocation:Houston, TX
Description:Texas Institute for Measurement, Evaluation, and Statistics
Post-Doctoral Associate in Neuropsychiatric Genetics
from: 2014, until: 2016Organization:Yale UniversityLocation:New Haven, CT
Description:Child Study Center, Yale School of Medicine
Education
Doctor of Philosophy - PhD
from: 2009, until: 2014Field of study:Experimental PsychologySchool:University of ConnecticutLocation:Storrs, CT
DescriptionNeurophysiological and Genetic Bases of Developmental Language Disorder (Co-Advised by Drs. James Magnuson and Nicole Landi).
NSF Integrative Graduate Education and Research Traineeship (IGERT) Associate
Doctor of Philosophy - PhD
from: 2009, until: 2012Field of study:Educational Psychology & PsychometricsSchool:Moscow State UniversityLocation:Moscow, Russia
DescriptionCross-Cultural Invariance of Analytical, Creative, and Practical Abilities of Russian, US, and UK Students
Master's degree - MA
from: 2009, until: 2011Field of study:General PsychologySchool:University of ConnecticutLocation:Storrs, CT
DescriptionLanguage and Cognition
Bachelor's degree - BSc (Specialist)
from: 2003, until: 2008Field of study:PsychologySchool:Moscow State UniversityLocation:Moscow, Russia
DescriptionDiploma with distinction (summa cum laude)
Specialized Training
Project Management in Biotechnology Program
from: Oct 2021, until: Aug 2022
Organization: University of Washington & UCSD .
Description:Seattle, WA
Next-Generation DNA Sequencing
from: Jun 2017, until: Jun 2017
Organization: National Human Genome Research Institute .
Description:Birmingham, AL
TETRAD: Graphical and Causal Modeling
from: Apr 2016, until: Apr 2016
Organization: American Statistical Association .
Description:Chicago, IL
Structural Equation Modeling
from: Feb 2010, until: Feb 2010
Organization: ARTS Seminar & Freie Universitat .
Description:Berlin, Germany
EEG Signal Processing and Source Localization
from: Apr 2012, until: Apr 2012
Organization: Cortech Solutions, Inc .
Description:San Diego, CA
Single-Case Intervention Research
from: Jan 2016, until: Jan 2016
Organization: American Psychological Association .
Description:Madison, WI
Selected Publications
Heterogeneity in statin responses explained by variation in the human gut microbiome
Journal ArticlePublisher:Cell MedDate:2022Authors:Tomasz WilmanskiSergey A KornilovChristian DienerMatthew P ConomosJennifer C LovejoyPaola SebastianiEric S OrwollLeroy HoodNathan D PriceNoa RappaportothersPlasma levels of soluble ACE2 are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19
Journal ArticlePublisher:Critical CareDate:2020Authors:Sergey A KornilovIsabelle LucasKathleen JadeChengzhen L DaiJennifer C LovejoyAndrew T MagisEffects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers
Journal ArticlePublisher:PLoS OneDate:2019Authors:Oxana Yu NaumovaSergey Yu RychkovSergey A KornilovVeronika V OdintsovaVarvara О AnikinaMaria Yu SolodunovaIrina A ArintcinaMarina A ZhukovaIrina V OvchinnikovaOlga V BurenkovaothersGenome-wide homozygosity mapping reveals genes associated with cognitive ability in children from Saudi Arabia
Journal ArticlePublisher:Frontiers in GeneticsDate:2019Authors:Sergey A KornilovMei TanAbdullah AljughaimanOxana Yu NaumovaElena L GrigorenkoLanguage outcomes in adults with a history of institutionalization: behavioral and neurophysiological characterization
Journal ArticlePublisher:Scientific ReportsDate:2019Authors:Sergey A KornilovMarina A ZhukovaIrina V OvchinnikovaIrina V GolovanovaOxana Yu NaumovaTatiana I LogvinenkoAleksandra O DavydovaMaxim V PetrovMaria A ChumakovaElena L GrigorenkoGenome-wide association and exome sequencing study of language disorder in an isolated population
Journal ArticlePublisher:PediatricsDate:2016Authors:Sergey A KornilovNatalia RakhlinRoman KoposovMaria LeeCarolyn YrigollenAhmet Okay CaglayanJames S MagnusonShrikant ManeJoseph T ChangElena L GrigorenkoLexical processing deficits in children with developmental language disorder: An event-related potentials study
Journal ArticlePublisher:Development and PsychopathologyDate:2015Authors:Sergey A KornilovJames S MagnusonNatalia RakhlinNicole LandiElena L GrigorenkoAttentional but not pre-attentive neural measures of auditory discrimination are atypical in children with developmental language disorder
Journal ArticlePublisher:Developmental NeuropsychologyDate:2014Authors:Sergey A KornilovNicole LandiNatalia RakhlinShin-Yi FangElena L GrigorenkoJames S Magnuson
Multiple early factors anticipate post-acute COVID-19 sequelae
Journal ArticlePublisher:CellDate:2022Authors:Y SuD YuanDG ChenRH NgK WangJ ChoiS LiS HongR ZhangJ XieothersManifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90
Journal ArticlePublisher:Scientific ReportsDate:2022Authors:Laura HeathJohn C EarlsAndrew T MagisSergey A KornilovJennifer C LovejoyCory C FunkNoa RappaportBenjamin A LogsdonLara M MangraviteBrian W KunkleothersIntegrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19
Journal ArticlePublisher:Nature BiotechnologyDate:2022Authors:Jihoon W LeeYapeng SuPriyanka BaloniDaniel ChenAna Jimena Pavlovitch-BedzykDan YuanVenkata R DuvvuriRachel H NgJongchan ChoiJingyi XieothersInitiation of ocrelizumab in patients with relapsing multiple sclerosis is associated with a broad immunomodulatory response implicating proinflammatory T-cells: a multi-omics study
Conference PaperPublisher:Multiple Sclerosis JournalDate:2022Authors:S KornilovA MagisN PriceR GelinasJ HeathJ AcostaP RepovicS CohanMapping the human genetic architecture of COVID-19
Journal ArticlePublisher:NatureDate:2021Authors:COVID-19 Host Genetics Initiative Writing GroupLatent profiles of personality traits related to decision making about social distancing (in Russia and Azerbaijan)
Journal ArticlePublisher:Psikhologicheskii zhurnalDate:2021Authors:TV KornilovaSA KornilovAmbulatory risk models for the long-term prevention of sepsis: Retrospective study
Journal ArticlePublisher:JMIR Medical InformaticsDate:2021Authors:Jewel Y LeeSevda MolaniChen FangKathleen JadeD Shane O'MahonySergey A KornilovLindsay T MicoJennifer J HadlockMulti-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses
Journal ArticlePublisher:ImmunityDate:2021Authors:Michele DonatoYiran LiuYapeng SuCheng L DaiSergey A KornilovMinas KaragiannisTheodoros MarantosYehudit Hasin-BrumshteinYudong D HeEvangelos J Giamarellos-BourboulisothersCharacteristics and factors associated with coronavirus disease 2019 infection, hospitalization, and mortality across race and ethnicity
Journal ArticlePublisher:Clinical Infectious DiseasesDate:2021Authors:Chengzhen L DaiSergey A KornilovRyan T RoperHannah Cohen-ClineKathleen JadeBrett SmithJames R HeathGeorge DiazJason D GoldmanAndrew T MagisothersEarly lexical development of children raised in institutional care in Russia
Journal ArticlePublisher:British Journal of Developmental PsychologyDate:2020Authors:Marina A ZhukovaSergey A KornilovStella N TseitlinMarina B EliseevaElena A VershininaRifkat J MuhamedrahimovElena L GrigorenkoMulti-omics resolves a sharp disease-state shift between mild and moderate COVID-19
Journal ArticlePublisher:CellDate:2020Authors:Yapeng SuDaniel ChenDan YuanChristopher LaustedJongchan ChoiChengzhen L DaiValentin VoilletVenkata R DuvvuriKelsey ScherlerPamela TroischothersHealth and disease markers correlate with gut microbiome composition across thousands of people
Journal ArticlePublisher:Nature communicationsDate:2020Authors:Ohad ManorChengzhen L DaiSergey A KornilovBrett SmithNathan D PriceJennifer C LovejoySean M GibbonsAndrew T Magis
Honors & Awards
Outstanding Doctoral Dissertation in Developmental Science
date: 2015-07-01Issuer:Society for Research in Child Development
Isabelle Liberman Award
date: 2014-06-06Issuer:University of Connecticut
Post-Doctoral Merit Award
date: 2015-06-06Issuer:Society for Neurobiology of Language
Service
European Workshop on Executive Functioning and Meta-Cognition
From: 2013
Main Organizer (with Dr. Natalia Rakhlin) on behalf of the International Society for the Study of Behavioural Development
Genetics of Language Consortium (GenLang)
From: 2016
Co-Founder and Member of Steering Committee
Behavioral Science for High School Students
From: 2004
To: 2007
Instructor at Moscow State University-led School of Young Psychologists
Peer Reviewer
Funding Agencies
Medical Research Council (United Kingdom)
Journals
Nature Communications
Scientific Reports
PLoS Medicine
PLoS One
American Journal of Medical Genetics Part B
Child Development
Applied Neuropsychology: Child
Learning and Individual Differences
Frontiers in Psychology
Advanced Science
Biology
Metabolites
Genes
Brain Sciences
Assessment
Sensors
Vaccines
Diagnostics
Journal of Clinical Laboratory Analysis
JMIR Formative Research
New Directions in Child and Adolescent Development
Nutrition, Metabolism and Cardiovascular Diseases
Therapeutic Advances in Infectious Disease
Organizations
SRCD - Society for Research in Child Development
from: 2014, until: 2018Organization:Member
Biohackers Collective
from: 2024, until: presentOrganization:Member - Seattle Chapter
Funded Projects
Multi-Omic Characterization of the Effects of Ocrelizumab in Patients with Relapsing-Remitting Multiple Sclerosis
date: 2021Organization:Roche Genentech
Description:Role:Investigator
PI:MagisClinical Sample Collection COVID-19 Patients to Align with NIAID National Study
date: 2020Organization:National Institutes of Health
Description:R01AI141953-02S2
Role: Investigator
PI: BaligaAnalysis of Immune and Organ Systems Responses in Patients with COVID-19
date: 2019Organization:Merck/BARDA
Description:HHSO10020160031C
Role: Investigator
PI: HeathSevere Learning Disabilities in Juvenile Delinquents: Presentation, Course, and Remediation
date: 2017Organization:National Institutes of Health
Description:P20HD091005
Role: Key Investigator
PI: GrigorenkoPsychophysiological Study of Residual Cognitive Development Deficits in Adults with a History of Institutionalization
date: 2016Organization:The Russian Foundation for Basic Research (RFBR)
Description:16-36-60046
Role: Principal InvestigatorAssessment of Language Development in Adolescents and Adults
date: 2016Organization:The Russian Foundation for Humanities (RGNF)
Description:16-36-01084
Role: Principal InvestigatorALEF: Development of a Standardized Assessment of Spoken and Written Arabic Language Development
date: 2014Organization:King Faisal University, Saudi Arabia
Description:Role: Project Director
PI: GrigorenkoImpact of Early Deprivation on Bio-Behavioral Indicators of Child Development
date: 2014Organization:The Russian Ministry of Science and Education
Description:Role: Investigator
PI: GrigorenkoFoundation for Alliance for Education
date: 2014Organization:Institute of Education Sciences
Description:Role: Investigator
PI: GrigorenkoThe Florida Learning Disabilities Research Center Project VI
date: 2014Organization:National Institutes of Health
Description:5P50HD052120
Role: Investigator
PIs: Wagner, Grigorenko